HRID904611

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2907

Cyclophosphamide

C7H15Cl2N2O2P

结构：COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1

HCID31703

Doxorubicin

C27H29NO11

结构：COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.Cl

HCID443939

Doxorubicin hydrochloride

C27H30ClNO11

PRODUCTS

生成物

结构：COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)C[C@@](O)(C(=O)CO)C[C@@H]3O[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1.O=P1(N(CCCl)CCCl)NCCCO1

HCID56841756

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6212

Chloroform

CHCl3

PROCEDURE

实验过程

To a dark orange solution of Doxorubicin (0.036 g), prepared from Doxorubicin hydrochloride as described in the previous experiment, in chloroform (100 ml) were added while stirring at 50° PLA (4.048 g), cis-Pta2Cl2 (0.495 g) and cyclophosphamide (0.381 g in 40 ml dichloromethane). The mixture was transferred to a 500 ml ball mill jar about one-third filled with pebbles, rotated overnight and worked up as reported in Example 1 to give two samples of average particle sizes of 250-425μ and 150-250μ.

WORKUP

后处理

additionwere added
additionfilled with pebbles
customto give two samples of average particle sizes of 250-425μ and 150-250μ

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-0ecf59725b2b46b29e17cb5bd3d85d29
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04419340
来源说明: uspto-grants-1983_12

反应 SMILES

[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]2[C:14]3=[C:15]([OH:32])[C:16]4[C:28](=[O:29])[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][C:26]=5[O:30][CH3:31])[C:20](=[O:21])[C:17]=4[C:18]([OH:19])=[C:13]3[CH2:12][C@@:11]([OH:37])([C:33]([CH2:35][OH:36])=[O:34])[CH2:10]2)[CH2:5][C@H:4]([NH2:38])[C@@H:3]1[OH:39].C[C@@H]1O[C@@H](O[C@@H]2C3=C(O)C4C(=O)C5C(=CC=CC=5OC)C(=O)C=4C(O)=C3C[C@@](O)(C(CO)=O)C2)C[C@H](N)[C@@H]1O.Cl.[CH2:80]1[CH2:86][O:85][P:83]([N:87]([CH2:91][CH2:92][Cl:93])[CH2:88][CH2:89][Cl:90])(=[O:84])[NH:82][CH2:81]1>C(Cl)(Cl)Cl>[CH2:80]1[CH2:86][O:85][P:83]([N:87]([CH2:91][CH2:92][Cl:93])[CH2:88][CH2:89][Cl:90])(=[O:84])[NH:82][CH2:81]1.[CH3:1][C@@H:2]1[O:7][C@@H:6]([O:8][C@@H:9]2[C:14]3=[C:15]([OH:32])[C:16]4[C:28](=[O:29])[C:27]5[C:22](=[CH:23][CH:24]=[CH:25][C:26]=5[O:30][CH3:31])[C:20](=[O:21])[C:17]=4[C:18]([OH:19])=[C:13]3[CH2:12][C@@:11]([OH:37])([C:33]([CH2:35][OH:36])=[O:34])[CH2:10]2)[CH2:5][C@H:4]([NH2:38])[C@@H:3]1[OH:39]