Amino 4-methylbenzene-1-sulfonate → 2-Amino-1-(4-chlorobenzoyl)-isoquinolinium-p-toluene sulfonate

HRID 904621Notes

Reaction equation

HRID 904621 reaction equation
[Cl:1][C:2]1[CH:19]=[CH:18][C:5]([C:6]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:11]=[CH:10][N:9]=2)=[O:7])=[CH:4][CH:3]=1.[C:20]1([CH3:31])[CH:25]=[CH:24][C:23]([S:26]([O:29][NH2:30])(=[O:28])=[O:27])=[CH:22][CH:21]=1>>[C:20]1([CH3:31])[CH:21]=[CH:22][C:23]([S:26]([O-:29])(=[O:27])=[O:28])=[CH:24][CH:25]=1.[NH2:30][N+:9]1[CH:10]=[CH:11][C:12]2[C:17](=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:8]=1[C:6](=[O:7])[C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 10965249Amino 4-methylbenzene-1-sulfonateHCID 122431051-(4-Chlorobenzoyl)-isoquinoline

Product 1

HCID 233111402-Amino-1-(4-chlorobenzoyl)-isoquinolinium-p-toluene sulfonateYield 88.5%

Procedure

The 1-(4-chlorobenzoyl)-isoquinoline prepared as described above is reacted with O-(p-toluenesulfonyl)-hydroxylamine as described in paragraph 3 of Example 1. The 2-amino-1-(4-chlorobenzoyl)-isoquinolinium-p-toluene sulfonate is obtained with a yield of 88.5%.

Sources & evidence

ORD record
ord-d7853b3a68ae43c2a76686db6d727919
Source dataset
uspto-grants-1983_12
Patent number
US04419355

Reaction notes

Loading…