Ethyl orthoformate → HCID 178423985, compound

HRID 904637Notes

Reaction equation

HRID 904637 reaction equation
[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[C:12]([CH3:16])[C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[N:9][N:8]=1)=[O:5].[CH2:17](OC(OCC)OCC)C>>[CH3:16][C:12]1[CH:13]=[CH:14][CH:15]=[C:2]2[C:3]=1[C:4](=[O:5])[N:6]([C:7]1[NH:11][N:10]=[N:9][N:8]=1)[CH:17]=[N:1]2

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178425478HCID 178425478, compound

Product 1

HCID 178423985HCID 178423985, compound

Procedure

A mixture of 1.3 g of 2-amino-6-methyl-N-(1H-tetrazol-5-yl)benzamide and 10 ml of triethoxymethane was heated at reflux for 1 hour. The mixture was then cooled and the solid which formed was separated by filtration, washed with ethanol and air dried to give 5-methyl-3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 280°-281° C. with decomposition. This compound has the following structural formula: ##STR3##

Workup

  1. temperaturewas heated
  2. temperatureat reflux for 1 hour
  3. temperatureThe mixture was then cooled
  4. customthe solid which formed
  5. customwas separated by filtration
  6. washwashed with ethanol and air
  7. customdried

Sources & evidence

ORD record
ord-b07d3ce068f14379a3ef47a8a1a3aa5d
Source dataset
uspto-grants-1983_12
Patent number
US04419357

Reaction notes

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