Ethyl orthoformate → HCID 178488824, compound

HRID 904641Notes

Reaction equation

HRID 904641 reaction equation
[NH2:1][C:2]1[C:15]([O:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([NH:6][C:7]1[NH:11][N:10]=[N:9][N:8]=1)=[O:5].[CH2:18](OC(OCC)OCC)C>>[CH3:17][O:16][C:15]1[CH:14]=[CH:13][CH:12]=[C:3]2[C:2]=1[N:1]=[CH:18][N:6]([C:7]1[NH:11][N:10]=[N:9][N:8]=1)[C:4]2=[O:5]

Participants

3

Reactant 2

HCID 31214Ethyl orthoformateHCID 178490498HCID 178490498, compound

Product 1

HCID 178488824HCID 178488824, compound

Procedure

A suspension of 5.3 g of 2-amino-3-methoxy-N-(1H-tetrazol-5-yl)benzamide in 30 ml of triethoxymethane was refluxed for 14 hours to give 8-methoxy-3-(1H-tetrazol-5-yl)-4(3H)-quinazolinone melting at about 260°-261° C. (dec) after recrystallization from dimethylformamide.

Workup

  1. temperaturewas refluxed for 14 hours

Sources & evidence

ORD record
ord-bf8aa0e678ae4012b4853ae7fee5e0da
Source dataset
uspto-grants-1983_12
Patent number
US04419357

Reaction notes

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