Phenol → HCID 135773210, compound

HRID 904690Notes

Reaction equation

HRID 904690 reaction equation
[C:1]1([OH:7])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[K+].[C:10]([C:13]1[CH:14]=[C:15]2[C:20](=[C:21]([CH2:24][CH2:25][CH3:26])[C:22]=1[OH:23])[N:19]=[C:18]([C:27]([O:29][CH3:30])=[O:28])[CH:17]=[C:16]2Cl)(=[O:12])[CH3:11]>>[C:10]([C:13]1[CH:14]=[C:15]2[C:20](=[C:21]([CH2:24][CH2:25][CH3:26])[C:22]=1[OH:23])[N:19]=[C:18]([C:27]([O:29][CH3:30])=[O:28])[CH:17]=[C:16]2[O:7][C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)(=[O:12])[CH3:11]

Participants

4

Reactant 3

HCID 996PhenolHCID 14797Potassium HydroxideHCID 136035444HCID 136035444, compound

Product 1

HCID 135773210HCID 135773210, compound

Procedure

Phenol (10.0 g) which had been crushed in a mortar and pestle, was added to crushed potassium hydroxide (0.36 g) in a flask which was immersed in an oil bath. This was stirred at 60°-65° C. for 5 minutes before methyl 6-acetyl-4-chloro-7-hydroxy-8-propyl-quinoline-2-carboxylate (1.0 g) was added. The whole was stirred at 60°-65° C. for 1.5 hours and the phenol was then removed by steam distillation.

Workup

  1. additionwas added
  2. customwas immersed in an oil bath
  3. additionwas added
  4. customthe phenol was then removed by steam distillation

Sources & evidence

ORD record
ord-9d86b9035c24482596c19d5a97342592
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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