反应详情

The product of step (a) in ethanol was saturated with hydrogen chloride gas and, when the heat of solvation subsided, the brown solution was heated to reflux on a steambath for 5 hours. The mixture was cooled and was treated with water, then concentrated and the pH of the mixture was adjusted to about 7 before extracting into ethyl acetate. The extract was washed with water, dried and evaporated to give a yellowish solid (6.2 g; 82%). NMR and mass spectra were consistent with the required structure.

1. temperatureheat of solvation
2. temperaturethe brown solution was heated
3. temperatureto reflux on a steambath for 5 hours
4. temperatureThe mixture was cooled
5. concentrationconcentrated
6. extractionbefore extracting into ethyl acetate
7. washThe extract was washed with water
8. customdried
9. customevaporated
10. customto give a yellowish solid (6.2 g; 82%)