反应详情

Diethyl 6-chloro-4-oxo-10-propyl-4H-pyrano[3,2-g]quinoline-2,8-dicarboxylate (1 g) and urea (50 g) were fused together at 175° C. for 6 hours. The solid after cooling was added to 70% sulphuric acid (200 ml) and heated on a steambath for 8 hours. The mixture was poured into ice-water (2 liters) and the precipitate was collected and washed well with water to afford the sub-title compound (0.15 g): identified by NMR spectroscopy.

1. temperatureThe solid after cooling
2. temperatureheated on a steambath for 8 hours
3. customthe precipitate was collected
4. washwashed well with water