Ammonia → HCID 135773209, compound

HRID 904704Notes

Reaction equation

HRID 904704 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([CH2:15][CH2:16][CH3:17])[C:13]=1[OH:14])[N:10]=[C:9]([C:18](OC)=[O:19])[CH:8]=[C:7]2[Cl:22])(=[O:3])[CH3:2].[NH3:23]>Cl>[C:1]([C:4]1[CH:5]=[C:6]2[C:11](=[C:12]([CH2:15][CH2:16][CH3:17])[C:13]=1[OH:14])[N:10]=[C:9]([C:18]([NH2:23])=[O:19])[CH:8]=[C:7]2[Cl:22])(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 136035444HCID 136035444, compound

Product 1

HCID 135773209HCID 135773209, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

Methyl 6-acetyl-4-chloro-7-hydroxy-8-propylquinoline-2-carboxylate (2 g) was treated with ammonia saturated methanol in an autoclave at 100° C. for 24 hours. Removal of solvent afforded a solid which was boiled with 2 N HCl (100 ml) for 10 minutes, then cooled, and the precipitate was collected and identified as the sub-title compound by NMR.

Workup

  1. customRemoval of solvent
  2. customafforded a solid which
  3. temperaturecooled
  4. customthe precipitate was collected

Sources & evidence

ORD record
ord-7349565f3bb3439cb6c05128b999fb58
Source dataset
uspto-grants-1983_12
Patent number
US04419352

Reaction notes

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