2-Hydroxybutanedioic acid--lysine (1/1) → HCID 131713241, compound

HRID 904791Notes

Reaction equation

HRID 904791 reaction equation
[C:1]([OH:9])(=[O:8])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3].[NH2:10][C@H:11]([C:17]([OH:19])=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][NH2:16]>C(O)C>[OH2:3].[C:1]([OH:9])(=[O:8])[C@H:2]([CH2:4][C:5]([OH:7])=[O:6])[OH:3].[NH2:10][C@H:11]([C:17]([OH:19])=[O:18])[CH2:12][CH2:13][CH2:14][CH2:15][NH2:16]

Participants

3

Reactant 1

HCID 717498192-Hydroxybutanedioic acid--lysine (1/1)

Product 1

HCID 131713241HCID 131713241, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In the same manner as described in Example 5, there is obtained an aqueous solution (185.3 g) of neutral L-lysine L-malate (concentration of the neutral L-lysine L-malate: 50% by weight). To a stirring vessel containing ethanol (500 ml) is gradually added the solution of neutral L-lysine L-malate obtained above to precipitate crystals well. The precipitated crystals are collected by filtration and air-dried at 40° C. overnight to give neutral L-lysine L-malate monohydrate (94 g, yield: 93.0%).

Workup

  1. customobtained above
  2. customto precipitate crystals well
  3. filtrationThe precipitated crystals are collected by filtration
  4. customair-dried at 40° C. overnight

Sources & evidence

ORD record
ord-3e3e44f147c44fb9b9a61cde017a8bf3
Source dataset
uspto-grants-1983_12
Patent number
US04420432

Reaction notes

Loading…