HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Trimethylsilyl-N-methylacetamide → 1-Isopropylsulfonyl-2-amino-6-(alpha-hydroxy-alpha-methylaminocarbonylmethylbenzyl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Trimethylsilyl-N-methylacetamide | HCID 81953 | — |
| Reactant | 2-Amino-6-benzoyl-1-((isopropyl)sulphonyl)-1H-benzimidazole | HCID 3017389 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | 1-Isopropylsulfonyl-2-amino-6-(alpha-hydroxy-alpha-methylaminocarbonylmethylbenzyl)benzimidazole | HCID 13286499 | — |
Reaction Steps
Following the general procedure of Example 23, N-methyl-N-trimethylsilylacetamide was reacted with 1-isopropylsulfonyl-2-amino-6-benzoylbenzimidazole in the presence of n-butyl lithium to provide 1-isopropylsulfonyl-2-amino-6-(α-hydroxy-α-methylaminocarbonylmethylbenzyl)benzimidazole. M.P. 92°-95° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420479 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-f4e5e231920543f78ea358305d2adef3 |
| Source note | uspto-grants-1983_12 |