Sodium Hydroxide → HCID 178508177, compound

HRID 904834Notes

Reaction equation

HRID 904834 reaction equation
C(S([N:7]1[C:11]2[CH:12]=[C:13]([C:16](=[CH:23][Cl:24])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[NH2:25])(=O)=O)(C)C.[OH-].[Na+]>CC(C)=O.O>[NH2:25][C:8]1[NH:9][C:10]2[CH:15]=[CH:14][C:13]([C:16](=[CH:23][Cl:24])[C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)=[CH:12][C:11]=2[N:7]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 53901979HCID 53901979, compound

Product 1

HCID 178508177HCID 178508177, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

1-Isopropylsulfonyl-2-amino-6-(α-chloromethylenebenzyl)benzimidazole is reacted with sodium hydroxide in acetone and water by the method of Example 43 to give 2-amino-6-(α-chloromethylenebenzyl)benzimidazole. The latter compound is reacted with phenylsulfonyl chloride and sodium hydroxide in dichloromethane to give 1-phenylsulfonyl-2-amino-6-(α-chloromethylenebenzyl)benzimidazole.

Sources & evidence

ORD record
ord-d1ea789a3c3a47b4b2a9b0ac95e685e6
Source dataset
uspto-grants-1983_12
Patent number
US04420479

Reaction notes

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