反应详情

A mixture of 12.0 g of 2-amino-4-chloro-5-sulfamylaniline, 16.1 g of propionic acid, and 54.4 ml of 4 N hydrochloric acid was refluxed for 6 hours. The solid was collected by filtration, dissolved in boiling methanol, charcoal added, and the solution filtered through Celite. Upon adding to 38% ammonium hydroxide with stirring, a pink solid formed. This was collected by filtration, washed with hot water, air dried, and then recrystallized from acetonitrile to provide 2.0 g of crystals, m.p. 240°-242°.

1. temperaturewas refluxed for 6 hours
2. filtrationThe solid was collected by filtration
3. dissolutiondissolved
4. additionadded
5. filtrationthe solution filtered through Celite
6. additionUpon adding to 38% ammonium hydroxide
7. customa pink solid formed
8. filtrationThis was collected by filtration
9. washwashed with hot water, air
10. customdried
11. customrecrystallized from acetonitrile