HRID904877

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID23665404

Sodium Acetate Trihydrate

C2H9NaO5

结构：CON=C(Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)c3csc(NC(=O)C(F)(F)F)n3)[C@H]2SC1)C(=O)O

HCID131713244

未命名化合物

PRODUCTS

生成物

结构：CON=C(Cn1nnnc1SCC1=C(C(=O)O)N2C(=O)C(NC(=O)C(=NOC)c3csc(N)n3)[C@H]2SC1)C(=O)O

HCID131713248

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A mixture of 7-[2-methoxyimino-2-{2-(2,2,2-trifluoroacetamido)thiazol-4-yl}acetamido]-3-[1-(2-carboxy-2-methoxyiminoethyl)-1H-tetrazol-5-yl]thiomethyl-3-cephem-4-carboxylic acid (syn isomer: in the 7-position) (1.70 g) and sodium acetate. trihydrate (3.26 g) in water (14 ml) was stirred overnight at room temperature. The solution was adjusted to pH 2.5 with 10% hydrochloric acid under ice-cooling and the resultant precipitates were filtered and washed with water to give 7-[2-methoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-[1-(2-carboxy-2-methoxyiminoethyl)-1H-tetrazol-5-yl]thiomethyl-3-cephem-4-carboxylic acid (syn isomer: in the 7-position).

WORKUP

后处理

temperaturecooling
customthe resultant precipitates
filtrationwere filtered
washwashed with water

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4ef5d1ebd5ad49f7a077a6788d072cbd
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04420477
来源说明: uspto-grants-1983_12

反应 SMILES

[CH3:1][O:2][N:3]=[C:4]([C:35]1[N:36]=[C:37]([NH:40]C(=O)C(F)(F)F)[S:38][CH:39]=1)[C:5]([NH:7][CH:8]1[C:33](=[O:34])[N:10]2[C:11]([C:30]([OH:32])=[O:31])=[C:12]([CH2:15][S:16][C:17]3[N:21]([CH2:22][C:23]([C:27]([OH:29])=[O:28])=[N:24][O:25][CH3:26])[N:20]=[N:19][N:18]=3)[CH2:13][S:14][C@H:9]12)=[O:6].O.O.O.C([O-])(=O)C.[Na+].Cl>O>[CH3:1][O:2][N:3]=[C:4]([C:35]1[N:36]=[C:37]([NH2:40])[S:38][CH:39]=1)[C:5]([NH:7][CH:8]1[C:33](=[O:34])[N:10]2[C:11]([C:30]([OH:32])=[O:31])=[C:12]([CH2:15][S:16][C:17]3[N:21]([CH2:22][C:23]([C:27]([OH:29])=[O:28])=[N:24][O:25][CH3:26])[N:20]=[N:19][N:18]=3)[CH2:13][S:14][C@H:9]12)=[O:6]