反应详情

A mixture of 20.0 g of 2-(p-prenylphenyl)propionic acid and 14.0 g of potassium carbonate in 150 ml of acetone was stirred at room temperature for one hour. To the solution was added dropwise a solution of 15.6 g of diethyl sulfate in 50 ml of acetone with stirring at 25° C. After stirring at room temperature for 3 hours, the mixture was refluxed for an additional one hour with stirring. The precipitate which formed was removed by filtration, and the acetone was evaporated. To the residue was added ice-water, and the mixture was extracted with n-hexane. The extract was washed with water, aqueous sodium bicarbonate and brine successively, and dried over anhydrous magnesium sulfate. The solvent was evaporated to give 18.7 g of ethyl 2-(p-prenylphenyl)propionate. b.p. 108° C./0.15 mmHg, IR νmaxneat ; 1730 cm-1.

1. stirringwith stirring at 25° C
2. stirringAfter stirring at room temperature for 3 hours
3. temperaturethe mixture was refluxed for an additional one hour
4. stirringwith stirring
5. customThe precipitate which formed
6. customwas removed by filtration
7. customthe acetone was evaporated
8. additionTo the residue was added ice-water
9. extractionthe mixture was extracted with n-hexane
10. washThe extract was washed with water, aqueous sodium bicarbonate and brine successively
11. dry with materialdried over anhydrous magnesium sulfate
12. customThe solvent was evaporated