HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dicyclohexylcarbodiimide → Z-Glu(OBzl)-Val-Thr(But)-OBut
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 5-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-glutamate | HCID 3049860 | — |
| Reactant | H-Val-Thr(But)-OBut.HCl | HCID 131713270 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Z-Glu(OBzl)-Val-Thr(But)-OBut | HCID 12944649 | — |
Reaction Steps
25.7 g of H-Val-Thr(But)-OBut.HCl are reacted, in 250 ml of dimethylformamide, with 26.0 g of Z-Glu-(OBzl)-OH and 15 g of DCC in the presence of 9.5 g of HOBt. After stirring for 6 hours the mixture is filtered and the filtrate is evaporated to dryness in vacuo. The residue is taken up in ethyl acetate, the solution is washed as described under (A) and, after drying and evaporating off the solvent, 37.3 g of the title compound are obtained with a melting point of 140°-144° (decomposition). Elementary analysis correct (C, H and N).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420424 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-667fbe6c43d94e98b5d1aa7159601041 |
| Source note | uspto-grants-1983_12 |