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HRID904951

反应详情

EQUATION

反应方程式

HRID 904951 的结构方程式

REACTANTS

反应物

4
结构：C(=NC1CCCCC1)=NC1CCCCC1
HCID10868

Dicyclohexylcarbodiimide

C13H22N2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：O=C(CC[C@H](NC(=O)OCc1ccccc1)C(=O)O)OCc1ccccc1
HCID3049860

Z-Glu(OBzl)-OH

C20H21NO6

结构：CC(C)[C@H](N)C(=O)N[C@H](C(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C.Cl
HCID131713270

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)[C@H](NC(=O)[C@H](CCC(=O)OCc1ccccc1)NC(=O)OCc1ccccc1)C(=O)N[C@H](C(=O)OC(C)(C)C)[C@@H](C)OC(C)(C)C
HCID12944649

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

25.7 g of H-Val-Thr(But)-OBut.HCl are reacted, in 250 ml of dimethylformamide, with 26.0 g of Z-Glu-(OBzl)-OH and 15 g of DCC in the presence of 9.5 g of HOBt. After stirring for 6 hours the mixture is filtered and the filtrate is evaporated to dryness in vacuo. The residue is taken up in ethyl acetate, the solution is washed as described under (A) and, after drying and evaporating off the solvent, 37.3 g of the title compound are obtained with a melting point of 140°-144° (decomposition). Elementary analysis correct (C, H and N).

WORKUP

后处理

  1. filtrationis filtered
  2. customthe filtrate is evaporated to dryness in vacuo
  3. washthe solution is washed
  4. customafter drying
  5. customevaporating off the solvent, 37.3 g of the title compound
  6. customare obtained with a melting point of 140°-144° (decomposition)