Z-Glu(OBzl)-Val-Thr(But)-OBut → Glu-Val-Thr(But)-OBut

HRID 904952Notes

Reaction equation

HRID 904952 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15]([NH:17][C@H:18]([C:22]([NH:24][C@H:25]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[C@@H:26]([CH3:32])[O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:16])[CH2:3][CH2:4][C:5](=[O:14])[O:6]CC1C=CC=CC=1>[Pd].CO>[NH2:1][C@H:2]([C:15]([NH:17][C@H:18]([C:22]([NH:24][C@H:25]([C:33]([O:35][C:36]([CH3:39])([CH3:38])[CH3:37])=[O:34])[C@@H:26]([CH3:32])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:23])[CH:19]([CH3:21])[CH3:20])=[O:16])[CH2:3][CH2:4][C:5](=[O:6])[OH:14]

Participants

4

Reactant 1

HCID 12944649Z-Glu(OBzl)-Val-Thr(But)-OBut

Product 1

HCID 131713271Glu-Val-Thr(But)-OBut

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

The compound obtained in accordance with (B) is subjected to catalytic hydrogenation over Pd in 80 percent strength methanol. The catalyst is filtered off and the solution is evaporated to dryness in vacuo. Triturating the residue with ether leads to a compound which is pure according to chromatography.

Workup

  1. filtrationThe catalyst is filtered off
  2. customthe solution is evaporated to dryness in vacuo
  3. customTriturating the residue with ether

Sources & evidence

ORD record
ord-d7f4229f67f640c3915c3b9ad22c34c4
Source dataset
uspto-grants-1983_12
Patent number
US04420424

Reaction notes

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