HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → H-Glu-Val-Val-OBut
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 5-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-glutamate | HCID 3049860 | — |
| Reactant | H-Val-Val-OBut.HCl | HCID 131713272 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | H-Glu-Val-Val-OBut | HCID 131713273 | — |
Reaction Steps
31 g of H-Val-Val-OBut.HCl are subjected, analogously to Example 21 (B), to a condensation reaction with 37 g of Z-Glu(OBzl)-OH in dimethylformamide in the presence of 13.5 g of HOBt and 12.8 ml of N-ethylmorpholine, by means of 22 g of DCC. After working up analogously to this example, catalytic hydrogenation is carried out as described in Example 21 (C). The compound insoluble in ether is isolated and is a single substance according to thin layer chromatography. Yield 51 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420424 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-fb0971d7b797436eb571404fb352eed0 |
| Source note | uspto-grants-1983_12 |