HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethylmorpholine → H-Glu-Ile-Phe-OBut
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethylmorpholine | HCID 7525 | — |
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | 5-(Phenylmethyl) hydrogen N-((phenylmethoxy)carbonyl)-L-glutamate | HCID 3049860 | — |
| Reactant | H-Ile-Phe-OBut.HCl | HCID 131713278 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | H-Glu-Ile-Phe-OBut | HCID 131713279 | — |
Reaction Steps
1.85 g of Z-Glu(OBzl)-OH, 1.85 g of H-Ile-Phe-OBut.HCl and 1.1 g of DCC are reacted, analogously to Example 21 (C), in the presence of 0.65 ml of N-ethylmorpholine and 0.7 g of HOBt in dimethylformamide, the product is subjected to catalytic hydrogenation and 2.4 g of the compound insoluble in ether are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420424 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-597aed4c12ed45e69d1288c3177c0dc6 |
| Source note | uspto-grants-1983_12 |