HRID904958

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7525

N-Ethylmorpholine

C6H13NO

HCID10868

Dicyclohexylcarbodiimide

C13H22N2

HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：O=C(CC[C@H](NC(=O)OCc1ccccc1)C(=O)O)OCc1ccccc1

HCID3049860

Z-Glu(OBzl)-OH

C20H21NO6

结构：CC[C@H](C)[C@H](N)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC(C)(C)C.Cl

HCID131713278

未命名化合物

PRODUCTS

生成物

结构：CC[C@H](C)[C@H](NC(=O)[C@@H](N)CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)OC(C)(C)C

HCID131713279

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3283

Diethyl Ether

C4H10O

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

1.85 g of Z-Glu(OBzl)-OH, 1.85 g of H-Ile-Phe-OBut.HCl and 1.1 g of DCC are reacted, analogously to Example 21 (C), in the presence of 0.65 ml of N-ethylmorpholine and 0.7 g of HOBt in dimethylformamide, the product is subjected to catalytic hydrogenation and 2.4 g of the compound insoluble in ether are isolated.

WORKUP

后处理

customare isolated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-597aed4c12ed45e69d1288c3177c0dc6
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04420424
来源说明: uspto-grants-1983_12

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:15](O)=[O:16])[CH2:3][CH2:4][C:5](=[O:14])[O:6]CC1C=CC=CC=1.[NH2:28][C@H:29]([C:34]([NH:36][C@H:37]([C:45]([O:47][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:46])[CH2:38][C:39]1[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=1)=[O:35])[C@H:30]([CH2:32][CH3:33])[CH3:31].Cl.C1CCC(N=C=NC2CCCCC2)CC1.C(N1CCOCC1)C.C1C=CC2N(O)N=NC=2C=1>CN(C)C=O.CCOCC>[NH2:1][C@H:2]([C:15]([NH:28][C@H:29]([C:34]([NH:36][C@H:37]([C:45]([O:47][C:48]([CH3:49])([CH3:51])[CH3:50])=[O:46])[CH2:38][C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1)=[O:35])[C@H:30]([CH2:32][CH3:33])[CH3:31])=[O:16])[CH2:3][CH2:4][C:5](=[O:6])[OH:14]