Acetic Acid → HCID 178476674, compound

HRID 904965Notes

Reaction equation

HRID 904965 reaction equation
[NH:1](C(OCC1C=CC=CC=1)=O)[C@H:2]([C:8]([NH:10][C@H:11]([C:19]([NH:21][C@H:22]([C:28]([NH:30][C@H:31]([C:35]([NH:37][C@H:38]([C:47]([OH:49])=[O:48])[CH2:39][C:40]1[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=1)=[O:36])[CH:32]([CH3:34])[CH3:33])=[O:29])[CH2:23][CH2:24][C:25](=[O:27])[OH:26])=[O:20])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:18])[NH2:17])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[C:60]([OH:63])(=[O:62])[CH3:61]>O>[NH2:1][C@H:2]([C:8]([NH:10][C@H:11]([C:19]([NH:21][C@H:22]([C:28]([NH:30][C@H:31]([C:35]([NH:37][C@H:38]([C:47]([O:49][CH3:60])=[O:48])[CH2:39][C:40]1[CH:45]=[CH:44][C:43]([OH:46])=[CH:42][CH:41]=1)=[O:36])[CH:32]([CH3:34])[CH3:33])=[O:29])[CH2:23][CH2:24][C:25](=[O:27])[OH:26])=[O:20])[CH2:12][CH2:13][CH2:14][NH:15][C:16](=[NH:18])[NH2:17])=[O:9])[CH2:3][CH2:4][CH2:5][CH2:6][NH2:7].[CH3:61][C:60]([OH:63])=[O:62]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 178448349HCID 178448349, compound

Product 1

HCID 178476674HCID 178476674, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

800 mg (approx. 0.88 mmole) of Z-Lys-Arg-Glu-Val-Tyr-Ome acetate are subjected to catalytic hydrogenation in 90 percent strength acetic acid and the product is worked up analogously to Example 25 I. Yield 680 mg (93%), [α]D22 =-31.6° (c=1, in water).

Sources & evidence

ORD record
ord-b5ae9bf3dd32482885cac3def746b99a
Source dataset
uspto-grants-1983_12
Patent number
US04420424

Reaction notes

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