HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → H-Tyr(But)-O-CH(CH3)2 hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | O-(1,1-Dimethylethyl)-N-((phenylmethoxy)carbonyl)-L-tyrosine | HCID 978520 | — |
| Reactant | Propylphosphoric anhydride | HCID 16167369 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | H-Tyr(But)-O-CH(CH3)2 hydrochloride | HCID 131713301 | — |
Reaction Steps
18.6 g (50 mmoles) of Z-Tyr(But)-OH in 30 ml of pyridine are reacted with 30 ml of isopropanol and 40 ml of a 50 percent solution of propylphosphonic anhydride in methylene chloride analogously to Example 30 A. The resulting oil is subjected to catalytic hydrogenation analogously to Example 25 B. The substance crystallizes from ether. Yield 13.15 g (83%), melting point 161°-163°, [α]D23 =+15.7° (c=1, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420424 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-de349d54dcca41ce95aa76394d9acfb9 |
| Source note | uspto-grants-1983_12 |