HRID904970

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID726987

Benzyloxycarbonyl-L-valine

C13H17NO4

结构：CC(C)OC(=O)[C@@H](N)Cc1ccc(OC(C)(C)C)cc1.Cl

HCID131713301

未命名化合物

PRODUCTS

生成物

结构：CC(C)OC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](NC(=O)OCc1ccccc1)C(C)C

HCID131713303

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

7.9 g (25 mmoles) of H-Tyr(But)-O-CH(CH3)2 hydrochloride and 6.27 g (25 mmoles) of Z-Val-OH are subjected to a condensation reaction analogously to Example 30 C. Yield 11.8 g (92%), melting point 133°-134°, [α]D26 =-25.2° (c=1, methanol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-de9a3ebc50ca48e499d15bd40f32ed0b
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04420424
来源说明: uspto-grants-1983_12

反应 SMILES

[NH2:1][C@H:2]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([CH3:14])([CH3:13])[CH3:12])=[CH:6][CH:5]=1.Cl.[NH:22]([C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[C@H:23]([C:27](O)=[O:28])[CH:24]([CH3:26])[CH3:25]>CO>[NH:22]([C:30]([O:32][CH2:33][C:34]1[CH:39]=[CH:38][CH:37]=[CH:36][CH:35]=1)=[O:31])[C@H:23]([C:27]([NH:1][C@H:2]([C:15]([O:17][CH:18]([CH3:20])[CH3:19])=[O:16])[CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:10][C:11]([CH3:14])([CH3:12])[CH3:13])=[CH:8][CH:9]=1)=[O:28])[CH:24]([CH3:26])[CH3:25]