HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Carbobenzoxy-L-valine → Z-Val-Tyr(But)-O-CH(CH3)2
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Carbobenzoxy-L-valine | HCID 726987 | — |
| Reactant | H-Tyr(But)-O-CH(CH3)2 hydrochloride | HCID 131713301 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Z-Val-Tyr(But)-O-CH(CH3)2 | HCID 131713303 | — |
Reaction Steps
7.9 g (25 mmoles) of H-Tyr(But)-O-CH(CH3)2 hydrochloride and 6.27 g (25 mmoles) of Z-Val-OH are subjected to a condensation reaction analogously to Example 30 C. Yield 11.8 g (92%), melting point 133°-134°, [α]D26 =-25.2° (c=1, methanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04420424 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-de9a3ebc50ca48e499d15bd40f32ed0b |
| Source note | uspto-grants-1983_12 |