HRID904975

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

2 次

结构：COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCCC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)C(C)C

HCID131713311

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](NC(=O)[C@H](N)CCCC(=O)OC(C)(C)C)C(C)C.Cl

HCID131713312

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

溶剂HCID178418361

未命名化合物

PROCEDURE

实验过程

Pd-on-charcoal catalyst is added to a solution of 2.3 g of Z-D-Aad(OBut)-Val-Tyr(But)-OMe in 100 ml of methanol and hydrogen is passed through the solution at pH 4.5 (autotitrator), while stirring and while adding approx. 2 N methanolic hydrochloric acid, until no further methanolic hydrochloric acid is taken up. The catalyst is then filtered off and the filtrate is concentrated. Yield 1.98 g, melting point 85°-87°, [α]D22 =-14.9° (c=1, methanol).

WORKUP

后处理

filtrationThe catalyst is then filtered off
concentrationthe filtrate is concentrated
customYield 1.98 g, melting point 85°-87°, [α]D22 =-14.9° (c=1, methanol)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ca9937fd8b104b3b8d160bcaaddf2756
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04420424
来源说明: uspto-grants-1983_12

反应 SMILES

[NH:1](C(OCC1C=CC=CC=1)=O)[C@@H:2]([C:13]([NH:15][C@H:16]([C:20]([NH:22][C@H:23]([C:36]([O:38][CH3:39])=[O:37])[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:27][CH:26]=1)=[O:21])[CH:17]([CH3:19])[CH3:18])=[O:14])[CH2:3][CH2:4][CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[ClH:50]>CO.[H][H]>[NH2:1][C@@H:2]([C:13]([NH:15][C@H:16]([C:20]([NH:22][C@H:23]([C:36]([O:38][CH3:39])=[O:37])[CH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[CH:27][CH:26]=1)=[O:21])[CH:17]([CH3:19])[CH3:18])=[O:14])[CH2:3][CH2:4][CH2:5][C:6]([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7].[ClH:50]