HRID904976

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID887

Methanol

CH4O

结构：CC(C)(C)OC(=O)C[C@@H](NC(=O)OCc1ccccc1)C(=O)O

HCID7016356

未命名化合物

结构：COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](N)C(C)C.Cl

HCID131713281

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)C(C)C

HCID131713318

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

6.46 g (20 mmoles) of Z-D-Asp(OBut)-OH are subjected to a condensation reaction with 7.73 g (20 mmoles) of H-Val-Tyr(But)-OMe.HCl in 50 ml of dimethylformamide analogously to Examples 38 A. Yield 11.2 g (85%), melting point 90°-92°, [α]D27 =-3.5° (c=1, methanol).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ca1839c983f148d385649f39415cb1e3
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04420424
来源说明: uspto-grants-1983_12

反应 SMILES

[NH:1]([C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[C@@H:2]([C:11]([OH:13])=O)[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:9])([CH3:8])[CH3:7].[NH2:24][C@H:25]([C:29]([NH:31][C@H:32]([C:45]([O:47][CH3:48])=[O:46])[CH2:33][C:34]1[CH:39]=[CH:38][C:37]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[CH:36][CH:35]=1)=[O:30])[CH:26]([CH3:28])[CH3:27].Cl.CO>CN(C)C=O>[NH:1]([C:14]([O:16][CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)=[O:15])[C@@H:2]([C:11]([NH:24][C@H:25]([C:29]([NH:31][C@H:32]([C:45]([O:47][CH3:48])=[O:46])[CH2:33][C:34]1[CH:35]=[CH:36][C:37]([O:40][C:41]([CH3:42])([CH3:43])[CH3:44])=[CH:38][CH:39]=1)=[O:30])[CH:26]([CH3:28])[CH3:27])=[O:13])[CH2:3][C:4](=[O:10])[O:5][C:6]([CH3:7])([CH3:8])[CH3:9]