51644-83-8 → HCID 131713319, compound

Participants

Reaction Steps

4.04 g (12 mmoles) of Z-D-Glu(OBut)-OH are subjected to a condensation reaction with 4.64 g (12 mmoles) of H-Val-Tyr(But)-OMe.HCl in 25 ml of dimethylformamide analogously to Example 38 A. Yield 6.72 g. The substance is purified further by chromatography on silica gel. The eluting agent is a mixture of methylene chloride and acetone in proportions such as 9:1. Yield 6.63 g (70%), melting point 100°-104°, [α]D27 =-8.4° (c=1, methanol).

Provenance & Evidence