HRID904977

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)CC[C@@H](NC(=O)OCc1ccccc1)C(=O)O

HCID6992708

未命名化合物

结构：COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](N)C(C)C.Cl

HCID131713281

未命名化合物

PRODUCTS

生成物

结构：COC(=O)[C@H](Cc1ccc(OC(C)(C)C)cc1)NC(=O)[C@@H](NC(=O)[C@@H](CCC(=O)OC(C)(C)C)NC(=O)OCc1ccccc1)C(C)C

HCID131713319

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

4.04 g (12 mmoles) of Z-D-Glu(OBut)-OH are subjected to a condensation reaction with 4.64 g (12 mmoles) of H-Val-Tyr(But)-OMe.HCl in 25 ml of dimethylformamide analogously to Example 38 A. Yield 6.72 g. The substance is purified further by chromatography on silica gel. The eluting agent is a mixture of methylene chloride and acetone in proportions such as 9:1. Yield 6.63 g (70%), melting point 100°-104°, [α]D27 =-8.4° (c=1, methanol).

WORKUP

后处理

customThe substance is purified further by chromatography on silica gel
additiona mixture of methylene chloride and acetone in proportions such as 9:1
customYield 6.63 g (70%), melting point 100°-104°, [α]D27 =-8.4° (c=1, methanol)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-7106905272524eaab5e96b0d9a12c298
来源数据集: uspto-grants-1983_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04420424
来源说明: uspto-grants-1983_12

反应 SMILES

[NH:1]([C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])[C@@H:2]([C:12]([OH:14])=O)[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:10])([CH3:9])[CH3:8].[NH2:25][C@H:26]([C:30]([NH:32][C@H:33]([C:46]([O:48][CH3:49])=[O:47])[CH2:34][C:35]1[CH:40]=[CH:39][C:38]([O:41][C:42]([CH3:45])([CH3:44])[CH3:43])=[CH:37][CH:36]=1)=[O:31])[CH:27]([CH3:29])[CH3:28].Cl>CN(C)C=O>[NH:1]([C:15]([O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:16])[C@@H:2]([C:12]([NH:25][C@H:26]([C:30]([NH:32][C@H:33]([C:46]([O:48][CH3:49])=[O:47])[CH2:34][C:35]1[CH:36]=[CH:37][C:38]([O:41][C:42]([CH3:43])([CH3:44])[CH3:45])=[CH:39][CH:40]=1)=[O:31])[CH:27]([CH3:29])[CH3:28])=[O:14])[CH2:3][CH2:4][C:5](=[O:11])[O:6][C:7]([CH3:8])([CH3:9])[CH3:10]