反应详情

Penicillin G, potassium salt (349.9 g) was dissolved in 3 liters of water. Sodium periodate (194 g) was added and the mixture was stirred for three hours. Dichloromethane (500 ml) was added and the pH of the water layer was adjusted to 2.3 with 6 N hydrochloric acid with vigorous stirring. The aqueous layer was separated and extracted with four 400 ml portions of dichloromethane. The combined extract was washed with aqueous sodium bisulfite to remove any iodine color, dried over sodium sulfate, filtered, and evaporated. The solid residue was empasted with 400 ml of ethyl acetate and allowed to stand at 0° C. overnight. The solid was isolated by filtration and dried in vacuo to afford 322 g of penicillin G sulfoxide.

1. customThe aqueous layer was separated
2. extractionextracted with four 400 ml portions of dichloromethane
3. extractionThe combined extract
4. washwas washed with aqueous sodium bisulfite
5. customto remove any iodine color
6. dry with materialdried over sodium sulfate
7. filtrationfiltered
8. customevaporated
9. waitto stand at 0° C. overnight
10. customThe solid was isolated by filtration
11. customdried in vacuo