Acetic Anhydride → HCID 54466988, compound

HRID 905024Notes

Reaction equation

HRID 905024 reaction equation
[F:1][C:2]([F:32])([CH2:7][CH2:8][C@H:9]([C@@H:11]1[C@:28]2([CH3:29])[C@H:14]([C@H:15]3[C@H:25]([CH2:26][CH2:27]2)[C@:23]2([CH3:24])[C:18]([CH2:19][C@@H:20]([OH:31])[CH2:21][C@@H:22]2[OH:30])=[CH:17][CH2:16]3)[CH2:13][CH2:12]1)[CH3:10])[C:3]([OH:6])([CH3:5])[CH3:4].C(O[C:37](=[O:39])[CH3:38])(=O)C>N1C=CC=CC=1.CN(C)C1C=CN=CC=1>[C:3]([O:30][C@@H:22]1[C@@:23]2([CH3:24])[C:18](=[CH:17][CH2:16][C@@H:15]3[C@@H:25]2[CH2:26][CH2:27][C@@:28]2([CH3:29])[C@H:14]3[CH2:13][CH2:12][C@@H:11]2[C@H:9]([CH3:10])[CH2:8][CH2:7][C:2]([F:32])([F:1])[C:3]([O:6][C:22](=[O:30])[CH3:21])([CH3:4])[CH3:5])[CH2:19][C@@H:20]([O:31][C:37](=[O:39])[CH3:38])[CH2:21]1)(=[O:6])[CH3:2]

Participants

5

Reactant 2

HCID 7918Acetic AnhydrideHCID 13189275HCID 13189275, compound

Product 1

HCID 54466988HCID 54466988, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 1049PyridineSolvent

Procedure

When a mixture of [1α,3β]-24,24-difluorocholest-5-en-1,3,25-triol in pyridine is reacted with acetic anhydride and a catalytic amount of 4-dimethylaminopyridine, [1α,3β]-24,24-difluorocholest-5-en-1,3,25-triol 1,3,25-triacetate can be obtained.

Sources & evidence

ORD record
ord-fa9c23c666744530b316f2d50c2c2d1e
Source dataset
uspto-grants-1983_12
Patent number
US04421690

Reaction notes

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