Hydrochloric Acid → HCID 20476827, compound

Participants

Reaction Steps

A solution prepared by adding 10 ml of water and 19 ml of 1N hydrochloric acid to 1.6 g of 4-(benzoylmethyl)-1-(cyanomethylamino)piperazine was cooled to 4° to 5° C., and with stirring, 1.7 g of sodium nitrite was added. The mixture was reacted at 4° to 5° C. for 1.5 hours with stirring. The reaction mixture was extracted with chloroform. The extract was washed with water and dried, and chloroform was distilled off to give 4-(benzoylmethyl)-1-(N-nitrosocyanomethylamino)piperazine as a red oil.

Provenance & Evidence