Hydrochloric Acid → HCID 20476827, compound

HRID 905032Notes

Reaction equation

HRID 905032 reaction equation
Cl.[C:2]([CH2:10][N:11]1[CH2:16][CH2:15][N:14]([NH:17][CH2:18][C:19]#[N:20])[CH2:13][CH2:12]1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N:21]([O-])=[O:22].[Na+]>O>[C:2]([CH2:10][N:11]1[CH2:12][CH2:13][N:14]([N:17]([CH2:18][C:19]#[N:20])[N:21]=[O:22])[CH2:15][CH2:16]1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 13200158HCID 13200158, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 20476827HCID 20476827, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution prepared by adding 10 ml of water and 19 ml of 1N hydrochloric acid to 1.6 g of 4-(benzoylmethyl)-1-(cyanomethylamino)piperazine was cooled to 4° to 5° C., and with stirring, 1.7 g of sodium nitrite was added. The mixture was reacted at 4° to 5° C. for 1.5 hours with stirring. The reaction mixture was extracted with chloroform. The extract was washed with water and dried, and chloroform was distilled off to give 4-(benzoylmethyl)-1-(N-nitrosocyanomethylamino)piperazine as a red oil.

Workup

  1. customA solution prepared
  2. temperaturewas cooled to 4° to 5° C.
  3. customThe mixture was reacted at 4° to 5° C. for 1.5 hours
  4. stirringwith stirring
  5. extractionThe reaction mixture was extracted with chloroform
  6. washThe extract was washed with water
  7. customdried
  8. distillationchloroform was distilled off

Sources & evidence

ORD record
ord-bd19899e0abb442390bc775e671a90ea
Source dataset
uspto-grants-1983_12
Patent number
US04421754

Reaction notes

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