Hydrazine hydrate (1:1) → HCID 178509161, compound

HRID 905037Notes

Reaction equation

HRID 905037 reaction equation
[C:1]([N:3]=[C:4]([N:7]1[CH2:12][CH2:11][N:10]([CH2:13][C:14]2[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)SC)#[N:2].O.[NH2:22][NH2:23]>C(O)C>[NH2:2][C:1]1[NH:3][C:4]([N:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:19]=[CH:18][C:17]([F:20])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)=[N:22][N:23]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 13267628HCID 13267628, compound

Product 1

HCID 178509161HCID 178509161, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The entire portion (0.1 mole) of N-cyano-4-(p-fluorobenzyl)-1-piperazinecarboximidothioic acid, methyl ester, prepared as an oil (Example 27) was dissolved in 150 ml. of ethanol and 5.5 ml. (0.11 mole) of hydrazine hydrate were added. The mixture was refluxed for 6 hours and then evaporated to a solid residue which as crystallized from 200 ml. of ethanol, giving 21 g. of the desired product as colorless crystals, m.p. 213°-216° C. (dec.).

Workup

  1. dissolutionwas dissolved in 150 ml
  2. temperatureThe mixture was refluxed for 6 hours
  3. customevaporated to a solid residue which
  4. customas crystallized from 200 ml
  5. customof ethanol, giving 21 g

Sources & evidence

ORD record
ord-e71b7d8007064e33bc7ed99b63c1e3f8
Source dataset
uspto-grants-1983_12
Patent number
US04421753

Reaction notes

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