Hydrochloric Acid → HCID 20477182, compound

HRID 905049Notes

Reaction equation

HRID 905049 reaction equation
[ClH:1].[F:2][CH:3]([F:26])[CH:4]([NH:18]C(OC(C)(C)C)=O)[CH2:5][CH2:6][CH:7]([NH:10]C(OC(C)(C)C)=O)[C:8]#[CH:9]>CCOCC>[ClH:1].[ClH:1].[F:2][CH:3]([F:26])[CH:4]([NH2:18])[CH2:5][CH2:6][CH:7]([NH2:10])[C:8]#[CH:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 20477184HCID 20477184, compound

Product 1

HCID 20477182HCID 20477182, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

A saturated solution of dry hydrogen chloride in dry ether (10 ml) is added to 1,1-difluoro-2,5-di-(N-tert.butoxycarbonylamino)-6-heptyne obtained as in Step E above (1 mmole) and left overnight at room temperature. The dichlorohydrate which forms as crystals is filtered, washed with ether, and dried to give the title compound (0.23 g).

Workup

  1. customobtained as in Step E above (1 mmole)
  2. filtrationis filtered
  3. washwashed with ether
  4. customdried

Sources & evidence

ORD record
ord-cc9cc1527d97416391fbd450faee2bfc
Source dataset
uspto-grants-1983_12
Patent number
US04421768

Reaction notes

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