Imidazole → HCID 53737547, compound

HRID 905061Notes

Reaction equation

HRID 905061 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].[Cl:8][C:9]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[C:10]=1[CH2:11][O:12][C@H:13]1[O:18][C@@H:17]([CH2:19]OS(C2C=CC(C)=CC=2)(=O)=O)[CH2:16][CH2:15][CH2:14]1>>[Cl:8][C:9]1[CH:34]=[CH:33][CH:32]=[C:31]([Cl:35])[C:10]=1[CH2:11][O:12][C@H:13]1[O:18][C@@H:17]([CH2:19][N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)[CH2:16][CH2:15][CH2:14]1

Participants

4

Reactant 3

HCID 795ImidazoleHCID 24758Sodium hydrideHCID 54030358HCID 54030358, compound

Product 1

HCID 53737547HCID 53737547, compoundYield 107%

Procedure

Using 103 mg of imidazole, 66 mg of 55% sodium hydride and 161 mg of cis-6-(2,6-dichlorobenzyloxy)-2-tosyloxymethyltetrahydropyran, the procedure described in Example 1(b) was repeated to give 132 mg of the title product in the form of a colourless oil.

Sources & evidence

ORD record
ord-8e2217c749bd4ad0b8c26b7355e2fe91
Source dataset
uspto-grants-1983_12
Patent number
US04421758

Reaction notes

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