反应详情

温度

20 °C

Pyridine (16 g, 0.2 mole) was added dropwise at 0° C. to a solution of 2-aminoethyl methacrylate hydrochloride (33 g, 0.2 mole) and diketene (16.8 g, 0.2 mole) in N,N-dimethylformamide (600 ml). After the addition, the solution was stirred at 20° C. for 20 hours. The solvent was then removed at low vacuum. The residue was dissolved in chloroform (1200 ml), washed with water (twice with 200 ml), dried over anhydrous magnesium sulfate and filtered. Excess solvent was then removed. Distillation of the residue gave acetoacetamidoethyl methacrylate (b.p.=113°-132° C./5μ) at a yield of 60%.

1. additionAfter the addition
2. customThe solvent was then removed at low vacuum
3. dissolutionThe residue was dissolved in chloroform (1200 ml)
4. washwashed with water (twice with 200 ml),
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. customExcess solvent was then removed
8. distillationDistillation of the residue