反应详情

Sodium iodide (30 mmol) was added to a solution of 2-chloromethylthio-5-chloropyrimidine (6.7 mmol) in acetone (30 ml) and the mixture heated under reflux for 4 h. The precipitated sodium chloride was removed by filtration, the filtrate evaporated to dryness, the residue triturated with water and recrystallized from ethanol; yield 86%, m.p. 67° C. 1H NMR (CDCl3): δ4.82 (SCH2), 8.67 (H-4, H-6).

1. temperaturethe mixture heated
2. temperatureunder reflux for 4 h
3. customThe precipitated sodium chloride was removed by filtration
4. customthe filtrate evaporated to dryness
5. customthe residue triturated with water
6. customrecrystallized from ethanol