反应详情

A mixture of 5-chloropyrimidine-2-thione (7.5 mmol), triethylamine (9 mmol) and 2-bromo-5-nitrothiophene (9 mmol) in dichloromethane (50 ml) was stirred at room temperature for 2 days. The resultant solution was then diluted with dichloromethane (50 ml), the solution shaken with 1 M NaOH (2×10 ml) and subsequently with water (10 ml), the dried (MgSO4) solution evaporated and the solid residue recrystallized from pet. ether; yield 63%, m.p. 141°-143° C. 1H NMR (CDCl3): δ7.16 and 7.83 (H-31, H-41), 8.53 (H-4, H-6).

1. dry with materialthe dried (MgSO4) solution
2. customevaporated
3. customthe solid residue recrystallized from pet. ether