HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl Isocyanate → 2-(N-Methylcarbamoyl)thio-5-chloropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl Isocyanate | HCID 12228 | — |
| Reactant | 5-Chloro-2(1H)-pyrimidinethione | HCID 7140345 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(N-Methylcarbamoyl)thio-5-chloropyrimidine | HCID 20475740 | 85% |
Reaction Steps
A mixture of 5-chloropyrimidine-2-thione (3 mmol) and methylisocyanate (4 mmol) in dichloromethane (15 ml) was stirred at room temperature for 2 h, the solvent was then distilled off and the residue was crystallised from CHCl3 : Pet. ether; yield 85%, m.p. 115° C. 1H NMR (CDCl3) δ3.03 (Me), 8.62 (H-4, H-6).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04423047 |
| Source dataset | uspto-grants-1983_12 |
| ORD ID | ord-a5bf9179c33d4bd596882dd04d0c11ed |
| Source note | uspto-grants-1983_12 |