Hydrogen Peroxide → HCID 20475746, compound

Participants

Reaction Steps

30% hydrogen peroxide solution (0.8 g) was added to a solution of 2-phenylthio-5-chloropyrimidine (5 mmol) in acetic acid (4 ml) and left at room temperature for 60 h). The solution was then diluted (25 ml) and the precipitate purified by thick-layer (2 mm) chromatography on silica gel 60F (Merck). The plates were developed with EtOAc; yield 50% m.p. 115° C. (ligroin). 1H NMR (CDCl3): δ7.4 and 7.8 (Ph), 8.71 (H-4, H-6).

Provenance & Evidence