Hydrogen Peroxide → HCID 20475746, compound

HRID 905238Notes

Reaction equation

HRID 905238 reaction equation
[OH:1]O.[C:3]1([S:9][C:10]2[N:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=2)[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>C(O)(=O)C>[C:3]1([S:9]([C:10]2[N:15]=[CH:14][C:13]([Cl:16])=[CH:12][N:11]=2)=[O:1])[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 20475704HCID 20475704, compound

Product 1

HCID 20475746HCID 20475746, compoundYield 50%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

30% hydrogen peroxide solution (0.8 g) was added to a solution of 2-phenylthio-5-chloropyrimidine (5 mmol) in acetic acid (4 ml) and left at room temperature for 60 h). The solution was then diluted (25 ml) and the precipitate purified by thick-layer (2 mm) chromatography on silica gel 60F (Merck). The plates were developed with EtOAc; yield 50% m.p. 115° C. (ligroin). 1H NMR (CDCl3): δ7.4 and 7.8 (Ph), 8.71 (H-4, H-6).

Workup

  1. additionThe solution was then diluted (25 ml)
  2. customthe precipitate purified by thick-layer (2 mm) chromatography on silica gel 60F (Merck)

Sources & evidence

ORD record
ord-36370c2d98234935b98faee019f07cd7
Source dataset
uspto-grants-1983_12
Patent number
US04423047

Reaction notes

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