Hydrochloric Acid → HCID 20475798, compound

HRID 905268Notes

Reaction equation

HRID 905268 reaction equation
[CH:1]1([CH2:6][CH2:7][NH:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([O:15]CC)=[O:14])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[K+].Cl>C(O)C.O>[CH:1]1([CH2:6][CH2:7][NH:8][C:9]2[CH:19]=[CH:18][C:12]([C:13]([OH:15])=[O:14])=[CH:11][CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 20475786HCID 20475786, compound

Product 1

HCID 20475798HCID 20475798, compound

Reagents, catalysts & solvents 1

HCID 19096565Water ethanolSolvent

Procedure

A solution of 2 g. of ethyl p-[2-(cyclopentyl)ethylamino]benzoate in 50 ml. of ethanol:water (9:1) containing 2 g. of potassium hydroxide is stirred at the reflux temperature under argon atmosphere for 3 hours. The chilled solution is acidified with concentrated hydrochloric acid, diluted with 45 ml. of water, and filtered to furnish 1.52 g. of white crystals. Recrystallization from ethanol/hexane provided product as white crystals.

Workup

  1. additiondiluted with 45 ml
  2. filtrationof water, and filtered
  3. customto furnish 1.52 g
  4. customRecrystallization from ethanol/hexane provided product as white crystals

Sources & evidence

ORD record
ord-856e24d390254961b797f5fc4b5d09f9
Source dataset
uspto-grants-1983_12
Patent number
US04423051

Reaction notes

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