Sodium Carbonate → N-[2-(benzylamino)ethyl]-2-phenylacetamide

HRID 905293Notes

Reaction equation

HRID 905293 reaction equation
Cl.[CH2:2]([NH:9][CH2:10][CH2:11][NH:12][C:13](=[O:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+]>O>[CH2:2]([NH:9][CH2:10][CH2:11][NH:12][C:13](=[O:21])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1

Participants

4

Reactant 2

HCID 10340Sodium CarbonateHCID 20446801HCID 20446801, compound

Product 1

HCID 12876177N-[2-(benzylamino)ethyl]-2-phenylacetamide

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The free base was liberated from the hydrochloride (15 g.) by basification of a solution in water (150 ml.) with solid sodium carbonate. The aqueous mixture was extracted with ethyl acetate (3×100 ml.) and the extracts were dried (MgSO4) and evaporated to give N-[2-(benzylamino)ethyl]-2-phenylacetamide as an oil (13.0 g.), which slowly crystallised.

Workup

  1. extractionThe aqueous mixture was extracted with ethyl acetate (3×100 ml.)
  2. dry with materialthe extracts were dried (MgSO4)
  3. customevaporated

Sources & evidence

ORD record
ord-d9c9257511134eb4b3038dac4b0a4ade
Source dataset
uspto-grants-1983_12
Patent number
US04423070

Reaction notes

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