Deoxyuridine → Deoxyuridine

HRID 905530Notes

Reaction equation

HRID 905530 reaction equation
[C@@H:1]1([N:9]2[CH:16]=[CH:15][C:13](=[O:14])[NH:12][C:10]2=[O:11])[O:8][C@H:5]([CH2:6][OH:7])[C@@H:3]([OH:4])[CH2:2]1.[P:17]([O-:21])([O-:20])([O-:19])=[O:18].[K+:22].[K+].[K+]>O>[CH2:2]1[C@H:1]([N:9]2[C:10](=[O:11])[NH:12][C:13](=[O:14])[CH:15]=[CH:16]2)[O:8][C@H:5]([CH2:6][OH:7])[C@H:3]1[OH:4].[OH:19][P:17]([O-:21])([OH:20])=[O:18].[K+:22]

Participants

5

Reactant 2

HCID 13712DeoxyuridineHCID 62657Potassium Phosphate, Tribasic

Product 2

HCID 13712DeoxyuridineHCID 516951Monobasic potassium phosphate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.4 grams (equal to 32 mMoles) of 2-chloroadenine were weighed and suspended while being stirred in 50 ml of DMSO. Solubilisation occurred with the addition of 70 ml of 25% (w:v) KOH, obtaining a perfectly clear solution with a 266 mMolar concentration of 2-chloroAdenine. 14.6 grams (equal to 64 mMoles) of 2′-deoxyuridine and 4 grams (equal to 30 mMoles) of anhydrous monobasic potassium phosphate were dissolved in about 600 ml of deionised water, obtaining a 106 mM for the 2-deoxyUridine and 50 mM for KH2PO4. The pH was corrected to a value of 7.5 with 25% (w:v) KOH as required.

Sources & evidence

ORD record
ord-8b49e00b6bdf4dafa5fb643bb52bd5ec
Source dataset
uspto-grants-2011_09
Patent number
US08012717B2

Reaction notes

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