HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → HCID 66897612, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | 8-Bromo-7-fluoro-2-methoxy-1,5-naphthyridine | HCID 45480320 | — |
| Product | HCID 66897612 | HCID 66897612 | 44.5% |
Reaction Steps
Starting from 8-bromo-7-fluoro-2-methoxy-[1,5]naphthyridine (10 g, 38.9 mmol) and diethyl malonate (17.9 mL, 116.7 mmol), the title compound (4.8 g, 17.3 mmol) was prepared as described in WO 2007/122258 for the analogous methyl ester. The purity of the material was around 80%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08012961B2 |
| Source dataset | uspto-grants-2011_09 |
| ORD ID | ord-88e479f978ad4653b5dc28c75b82fa7c |
| Source note | uspto-grants-2011_09 |