Diethyl Malonate → HCID 66897612, compound

HRID 905559Notes

Reaction equation

HRID 905559 reaction equation
Br[C:2]1[C:3]([F:14])=[CH:4][N:5]=[C:6]2[C:11]=1[N:10]=[C:9]([O:12][CH3:13])[CH:8]=[CH:7]2.[C:15](OCC)(=O)[CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[CH2:20]([O:19][C:17](=[O:18])[C:16]([C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:12][CH3:13])[N:10]=2)[N:5]=[CH:4][C:3]=1[F:14])=[CH2:15])[CH3:21]

Participants

3

Reactant 2

HCID 7761Diethyl MalonateHCID 454803208-Bromo-7-fluoro-2-methoxy-1,5-naphthyridine

Product 1

HCID 66897612HCID 66897612, compoundYield 44.5%

Procedure

Starting from 8-bromo-7-fluoro-2-methoxy-[1,5]naphthyridine (10 g, 38.9 mmol) and diethyl malonate (17.9 mL, 116.7 mmol), the title compound (4.8 g, 17.3 mmol) was prepared as described in WO 2007/122258 for the analogous methyl ester. The purity of the material was around 80%.

Sources & evidence

ORD record
ord-88e479f978ad4653b5dc28c75b82fa7c
Source dataset
uspto-grants-2011_09
Patent number
US08012961B2

Reaction notes

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