Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
N,N'-Dimethylethylenediamine → 1-[4-(1-Methoxy-1-methyl-ethyl)-phenyl]-3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | N,N'-Dimethylethylenediamine | HCID 8070 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 1-Bromo-4-(2-methoxypropan-2-yl)benzene | HCID 15072385 | — |
| 반응물 | 3-(2-Piperazin-1-yl-benzyl)-pyrrolidin-2-one | HCID 59782560 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-[4-(1-Methoxy-1-methyl-ethyl)-phenyl]-3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one | HCID 59782567 | 64% |
반응 단계
3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one (6) (1.2 grams) was subsequently allowed to react with 1.27 g of 1-bromo-4-(1-methoxy-1-methyl-ethyl)-benzene (11) in the presence of 0.041 grams of N,N′-dimethylethylenediamine, 0.088 g of CuI and 0.96 grams of K2CO3 in toluene (6 mL) at 110° C. for 17 hours to provide 1.2 grams of the racemate 1-[4-(1-methoxy-1-methyl-ethyl)-phenyl]-3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one (12) (64% yield) following silica gel chromatography (40:1:0.5 chloroform-methanol-ammonium hydroxide); MS (AP/CI) observed: 408.2 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08012969B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-1d27c8dd34804c87a1415110fcf4e794 |
| 출처 메모 | uspto-grants-2011_09 |