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HRID905610

反应详情

EQUATION

反应方程式

HRID 905610 的结构方程式

REACTANTS

反应物

4
结构：CNCCNC
HCID8070

N,N'-Dimethylethane-1,2-diamine

C4H12N2

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：COC(C)(C)c1ccc(Br)cc1
HCID15072385

1-Bromo-4-(2-methoxypropan-2-yl)benzene

C10H13BrO

结构：O=C1NCCC1Cc1ccccc1N1CCNCC1
HCID59782560

未命名化合物

PRODUCTS

生成物

1
结构：COC(C)(C)c1ccc(N2CCC(Cc3ccccc3N3CCNCC3)C2=O)cc1
HCID59782567

未命名化合物

收率 64%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Cu][I]
催化剂HCID24350

Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

CuI

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one (6) (1.2 grams) was subsequently allowed to react with 1.27 g of 1-bromo-4-(1-methoxy-1-methyl-ethyl)-benzene (11) in the presence of 0.041 grams of N,N′-dimethylethylenediamine, 0.088 g of CuI and 0.96 grams of K2CO3 in toluene (6 mL) at 110° C. for 17 hours to provide 1.2 grams of the racemate 1-[4-(1-methoxy-1-methyl-ethyl)-phenyl]-3-(2-piperazin-1-yl-benzyl)-pyrrolidin-2-one (12) (64% yield) following silica gel chromatography (40:1:0.5 chloroform-methanol-ammonium hydroxide); MS (AP/CI) observed: 408.2 (M+H)+.