HRID905621

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8471

Triethylamine

C6H15N

HCID95102

1,1-Dimethylethanolamine

C4H11NO

反应SMILES：CCCCOc1nc(N)c2nc(OC)n(CCCCBr)c2n1

HCID23158511

未命名化合物

HCID23388821

未命名化合物

PRODUCTS

产物

反应SMILES：CCCCOc1nc(N)c2[nH]c(=O)n(CCCCN(CC(C)(C)O)S(=O)(=O)c3cccc(CC(=O)OC)c3)c2n1

HCID11713966

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The compound obtained in Example 2-13 step (i) (371 mg) and 1-amino-2-methylpropane-2-ol (400 mg) were dissolved in acetonitrile (5 ml) and the same manner to Example 2-19 using triethylamine (0.055 ml) and methyl [3-(chlorosulfonyl)phenyl]acetate(93 mg) was conducted to give the titled compound as a white solid. Yield: 140 mg (24%); mp 192-193° C., MS APCI+ve 579 (M+H).

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-08f42d26f8ce4071ab8670c53ae0cedd
来源数据集: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08012964B2
来源说明: uspto-grants-2011_09

反应SMILES

Br[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[C:14]([O:15]C)=[N:13][C:12]2[C:7]1=[N:8][C:9]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])=[N:10][C:11]=2[NH2:17].[NH2:23][CH2:24][C:25]([CH3:28])([OH:27])[CH3:26].C(N(CC)CC)C.Cl[S:37]([C:40]1[CH:41]=[C:42]([CH2:46][C:47]([O:49][CH3:50])=[O:48])[CH:43]=[CH:44][CH:45]=1)(=[O:39])=[O:38]>C(#N)C>[NH2:17][C:11]1[N:10]=[C:9]([O:18][CH2:19][CH2:20][CH2:21][CH3:22])[N:8]=[C:7]2[C:12]=1[NH:13][C:14](=[O:15])[N:6]2[CH2:5][CH2:4][CH2:3][CH2:2][N:23]([CH2:24][C:25]([OH:27])([CH3:28])[CH3:26])[S:37]([C:40]1[CH:41]=[C:42]([CH2:46][C:47]([O:49][CH3:50])=[O:48])[CH:43]=[CH:44][CH:45]=1)(=[O:39])=[O:38]