Triethylamine → Methyl [3-({[2-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)ethyl]amino}sulfonyl)phenyl]acetate

HRID 905623Notes

Reaction equation

HRID 905623 reaction equation
[NH2:1][CH2:2][CH2:3][N:4]1[C:12]([O:13]C)=[N:11][C:10]2[C:5]1=[N:6][C:7]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])=[N:8][C:9]=2[NH2:15].C(N(CC)CC)C.Cl[S:29]([C:32]1[CH:33]=[C:34]([CH2:38][C:39]([O:41][CH3:42])=[O:40])[CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30]>C(#N)C>[NH2:15][C:9]1[N:8]=[C:7]([O:16][CH2:17][CH2:18][CH2:19][CH3:20])[N:6]=[C:5]2[C:10]=1[NH:11][C:12](=[O:13])[N:4]2[CH2:3][CH2:2][NH:1][S:29]([C:32]1[CH:33]=[C:34]([CH2:38][C:39]([O:41][CH3:42])=[O:40])[CH:35]=[CH:36][CH:37]=1)(=[O:31])=[O:30]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 23388821Methyl [3-(chlorosulfonyl)phenyl]acetateHCID 589428299-(2-Aminoethyl)-butoxy-8-methoxy-9H-purin-6-amine

Product 1

HCID 11705634Methyl [3-({[2-(6-amino-2-butoxy-8-oxo-7,8-dihydro-9H-purin-9-yl)ethyl]amino}sulfonyl)phenyl]acetate

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The compound obtained in Example 2-1 step (vii) (245 mg), triethylamine (0.13 ml) and methyl [3-(chlorosulfonyl)phenyl]acetate (217 mg) were dissolved in acetonitrile (5 ml) and the same manner to Example 2-13 step (iii) was conducted to give the titled compound as a white solid. Yield: 40 mg (9%); MS APCI+ve 479 (M+H).

Sources & evidence

ORD record
ord-1e8819420b5149e0bc048f88b1ba4e63
Source dataset
uspto-grants-2011_09
Patent number
US08012964B2

Reaction notes

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